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147 written by Dr. Frank Lipman in Healthy Aging
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Nov 24, 2025 · Healthy AgingMeet 5 Common Meds That Can Put Your Brain in Dementia’s Path
When we think about Alzheimer’s, we often think of it as a disease that happens because of age, or maybe as the result of a life lived too hard or just plain old bad luck in the genetics department. While age and genes certainly do play a role, they’re not the whole story. More and more research is pointing to another, more under-the-radar factor. It turns out that certain common medications may speed up brain aging. In fact, many of the meds that are used to treat everyday issues, both prescription and over-the-counter, may be surreptitiously increasing your risk of dementia, including Alzheimer’s, the most common severe form of the condition.
Nov 17, 2025 · Healthy AgingSupport Vibrant Longevity with Dr. Lipman’s 15 Favorite, Super Savvy Supplements
Traveling the longevity path requires a proactive effort on our part – it’s not a one-and-done deal. It’s about creating a road map that combines health and longevity-promoting lifestyle habits with cutting-edge scientific innovations and treatment modalities, including a custom tailored program of longevity-supporting supplements to enhance quality of life and reduce the risks of disease and early mortality. So, how do we get there? I have a few thoughts on the topic.
Nov 10, 2025 · Healthy AgingNAD To the Rescue – and 7 Smart Ways to Support Your Cells
With so many health headlines making news every day, it’s easy for even my well-informed patients to feel like they’re drowning in too much information. That’s where my team and I come in: to sift through the noise, explain the science, and guide people toward sensible, evidence-based choices tailored to their exact life situation and physiology. Lately, I’ve had a lot of questions about NAD, something I’m naturally a fan of -- we couldn’t live without it! But about the trendy NAD “shots” or infusions, truth be told, I’m less enthusiastic. Why? Well, I have a few thoughts on that.
Oct 27, 2025 · Healthy AgingHeat Shock Proteins: The Under-the-Radar Longevity Booster Worth Cultivating
Heat shock proteins – don’t let the odd name fool you. The phrase sounds as if we’re talking about proteins that are suffering from too much heat exposure, and that can’t be good. And, in a way, that’s actually not too far off. Heat shock proteins, or HSPs, are a special class of proteins that adapt to the stresses of living, including but by no means limited to exposure to heat, by becoming extra-resilient. In fact, they become so resilient, they’re able to help ordinary proteins repair themselves when they’re subjected to those same pressures. Pretty cool, eh?
Oct 20, 2025 · Healthy AgingMore than Just Jet-Lag Helper: How Mighty Melatonin May Guard Your Brain, Mitochondria, and Longevity
Chances are, you’ve probably taken melatonin from time to time when struggling with sleep or crisscrossing time zones. The idea is that as evening falls, your primary energy hormone cortisol drops and melatonin goes up, cueing the body for sleep, which is why some have dubbed melatonin “the hormone of darkness.” Well, guess what? Melatonin is stepping into the spotlight to help aging brains The latest research has revealed that it’s produced in the mitochondria, the cell powerplants, in a number of your organs, and that it’s involved a wide range of important physiological processes, some of which have nothing directly to do with sleep – and more to do with brain health over the long haul.
Oct 6, 2025 · Healthy AgingGet the NAC: Anti-aging’s All-Purpose, Easy-to-Love Little Helper
It’s fairly common in medicine for a drug to be developed to treat one condition which then turns out to have broader application, however, pharma drugs, usually come with side-effects. But how about a supplement that has been used for decades to treat a number of conditions? And, one which subsequent research shows also pushes back against the basic processes that drive aging? And may also treat the diseases of aging that ultimately hobble or end most of our lives with negligible side-effects? That would be something, right? Well, if you’re not familiar, let me introduce you to N-Acetyl Cysteine or NAC.
Sep 29, 2025 · Healthy AgingYour Resilience Prescription: 8 Smart Strategies for Creating Physical and Mental Longevity
Almost every day in the longevity world, a new discovery pops up and another exciting tool lands in our “longevity toolbox.” In just a few short years, advances have not only changed how we understand aging but have begun to reshape the process of aging itself. So, these days, aging feels less about fear and dread, and a lot more about “let’s do this vibrantly and well!” But amid all this progress, one of our most mission-critical “tools” isn’t a high-tech lab test or a breakthrough treatment. It’s resilience — the ability to bend without breaking, to take life’s hits and bounce back. Without it, even the most cutting-edge interventions can’t fully work their magic. So, cultivate it we must.
Sep 22, 2025 · Healthy AgingDig Into Polyphenol’s, Nature’s Tastiest Anti-Aging Must-Have
In my longevity-focused practice, putting the brakes on aging so that people can stay healthy, strong, and vibrant for decades is my top priority. While I’ve got a deep bench of longevity strategies, one of my go-tos is also one of the best tasting -- polyphenols. They’re a large family of plant compounds found in colorful fruits and veggies, herbs, cocoa, tea, coffee, and extra-virgin olive oil, that give plants their flavor, color, and natural defenses – and in turn help protect you too. Done right, and enjoyed often, polyphenols are a mighty (and tasty) ally in your quest for a long, vibrant life.
Sep 8, 2025 · Healthy AgingSlow Aging With Your Built-in Anti-Ager, Autophagy
Although scientists have known about autophagy for decades, it's only in the last decade or so it’s found its way into the spotlight as one of the body’s most important tools for staying youthful and resilient. Once just a phrase buried in biology textbooks, autophagy is now at the front and center of longevity research, turning heads for its potential to slow aging, boost vitality, and reshape how we think about long-term health. One way to think of autophagy is as your body’s built-in cleanse-and-repair system, quietly working behind the scenes to help you feel sharper, stronger, and better equipped to handle whatever life throws your way.
Sep 1, 2025 · Healthy Aging6 Aging Myths to Stop Buying Into – So You Can Make Your Years Amazing!
Aging is a privilege. Every day we get to take a breath deserves our gratitude. Yes, the passing years may bring their share of physical quirks, but the doom-and-gloom narrative around aging? Overhyped, and in need of a serious rewrite. I’m not saying we’ll all be training to summit Everest deep into our 70s. But I am saying that aging doesn’t have to mean physical and mental collapse. Thanks to some recent waves of longevity research, sparked in part by Boomers and Gen Xers asking, “What if we don’t go gently into that good night?” we now know that many aging “facts” that generations have held dear are actually fiction.
Aug 25, 2025 · Healthy AgingMore than Just Fun and Games: 5 Ways Social Connection Supports Longevity
When we think about living a long and healthy life, we tend to focus on the usual suspects: eating well, exercising, sleeping enough, managing stress. All, very important stuff. But one powerful pillar often gets overlooked—human connection. It turns out that meaningful relationships are just as essential as veggies and regular movement. That’s why I encourage my patients to rekindle connections, nurture the good ones they already have, and stay open to new ones. Sure, it’s easier to hibernate—but, if you want to live longer and healthier, it’s time to shake things up socially.
Aug 18, 2025 · Healthy AgingGlutathione and Longevity: The Antioxidant That Supports Strength and Health
Often called the body’s “master antioxidant,” glutathione takes care of a lot of body business: protecting your cells, supporting detoxification, keeping your immune system humming, and just possibly helping to slow the hands of time (yes, please!). What’s more, your body makes it all by itself. But — and it’s a big but — under certain fairly common circumstances, production can start to sputter. Classic health-eroders like aging, stress, poor diet, and toxic exposure, either on their own or in combo, can all chip away at your natural supply, setting the stage for fatigue and disease far too early in life. Your mission? To keep your tank topped up.
Aug 11, 2025 · Healthy Aging6 Ways Metabolism Can Keep You Younger Longer – or If Done Wrong, Can Age You Faster
We are all aging, but we all seem to do it at different rates. For instance, one friend might pass for a decade younger and another, well, let’s just say, may present somewhat older than their chronological age. So, what’s going on? Sure, genetics plays a role but to a large degree, as the research of the past decade has made plain, the aging process is driven by metabolism. When our metabolism is working the way nature intended it to, we’re on track to live hale and hearty lives into our 80s and maybe beyond. When it’s not, metabolism becomes the driver –often the main one – behind the classic “diseases of aging” – that can rob you of countless good years as you age.
Aug 4, 2025 · Healthy Aging5 Ways the Peptide BPC 157 Can Help Repair, Restore and Rejuvenate
While it is hard to pick a favorite peptide – there are that many to choose from – one that’s especially close to my heart (and knees) is Body Protection Compound 157, better known as BPC 157—or simply BPC. I use it regularly, both in my practice and in my own life. Peptides like BPC 157, are short chains of amino acids — essentially mini-proteins — that signal specific biological actions. Studies show that certain peptides can support tissue repair, immune regulation, metabolism, and even brain health. Unlike general supplements or standard issue pharmaceuticals, peptides tend to behave more like precisely targeted messengers, mimicking natural hormones or enzymes in the body.
Jul 28, 2025 · Healthy Aging8 Things to Know About How Ketones Can Help Nourish, Protect and Save Your Brain from Decline
Long associated with ketogenic diets and ‘fat-burning,’ ketones are actually one of the most underappreciated (power) tools we have, not just for sustained physical energy, but for enhancing brain function and protecting long-term cognitive health. In fact, ketones might just be your brain's favorite fuel (who knew?). They’re the total energy package: a clean, efficient, and highly neuroprotective energy source which your body can make on its own — or you can get more in supplement form for that extra mental and physical edge.
Jul 14, 2025 · Healthy AgingBetter Brain Function for Life? Parsing the Promise of Plasmalogens
Recently, excitement about plasmalogens has been growing thanks to emerging evidence suggesting that they may be able to protect against cognitive decline and reduce the risk of devastating neurodegenerative diseases like Alzheimer’s. Given that the side-effects appear to be virtually non-existent, plasmalogen supplements might be something to consider exploring, particularly if you have reason to believe you may be at higher than average risk for neurodegenerative diseases like Alzheimer’s.
Jun 23, 2025 · Healthy AgingApproaching the Fountain of Youth: The Link Between Longevity and Diabetes Medications
Now that we know so much about the biology of aging, and the 12 major markers of aging, can we actually treat it? Can we slow aging down, or even reverse some of it’s effects? The answer is getting closer every day. In fact, we may already have some powerful tools at hand. But only now are we beginning to understand how best to use them. So, which ones may be the game changers when it comes to living better for longer? The most promising ‘big three’ tools currently in our longevity toolbox may just be the game-changers we’ve all been waiting for – thanks to, of all things, diabetes.
Jun 16, 2025 · Healthy AgingMeet Methylation – The Fast Pass to The Feeling Great Train at Every Age
When we talk about methylation, we’re talking organic chemistry. It’s a natural chemical process whereby a tiny group of atoms (one carbon and three hydrogen atoms—aka, a “methyl group”) is passed from one molecule to another. This tiny hand-off is actually a big deal. It helps regulate gene expression, that is, it helps determines which genes get turned on or off. That, in turn, determines which proteins your body makes and when – and proteins, remember, are the workhorses of the body, responsible for practically everything that happens inside us. Think of it like oiling the gears of a machine—without methylation, the body’s gears start to jam up.
Jun 2, 2025 · Healthy AgingHow Calorie Restriction Mimetics May Slow the Hands of Time
What if you could harness the longevity-supportive benefits of calorie restriction (CR) without actually having to eat less? That’s where ‘calorie restriction mimetics’ (CRMs) come in, compounds that mimic the beneficial effects of CR. Here’s an introduction to this fascinating, and fast-evolving, anti-aging science, and a look at how CRMs may help you keep a spring in your step for as long as possible.
May 26, 2025 · Healthy Aging8 Circadian Rhythm Tune-Up Tips to Help Slow Aging
The clock is ticking, time is passing, and few of us are getting any younger – well, make that none of us. But there are a number of ways to slow the hands of time. One of the easiest, and most direct, ways is to take advantage of the clock that’s built into every one of us -- the internal master clock, aka your circadian rhythm, which runs on a 24-hour cycle. That inner clock is what helps regulate when you feel sleepy or alert, when you’re hungry, and even how your body fights off illness.
May 19, 2025 · Healthy Aging1-MNA: The Anti-Aging, Heart-Helping Wellness Wonder
1-MNA, is a naturally occurring compound produced when the body breaks down niacin/vitamin B3 in the diet or supplements. And everything just goes better with MNA, especially the conversion of food into energy which is the main business of B3. What makes 1-MNA especially easy to love? Its solid safety stats; its ability to help naturally restore levels of NAD (aka nicotinamide adenine dinucleotide, the “coenzyme” that helps turn that food into energy); and to optimize the complex network of cellular pathways involved in energy generation. It’s a boon to your cardiovascular system and so much more that I encourage everyone to consider this smart addition to your wellness repertoire.
May 12, 2025 · Healthy AgingSleep: The Ultimate Anti-Aging Tool for Keeping Brains Young and Healthy
When we think about the common signs of aging, we often we think about the obvious everyday externals, like wrinkles and thinning hair, or the need for increasingly more powerful reading glasses. But when it comes to longevity, it’s pretty clear that what's going on in your head is ultimately far more important than what it looks like on the outside. While fillers and Botox can shore up an aging face, what are the most important ‘tweakments’ to help keep your brain young? There are a number of must-dos, but the real chart-trooper is sleep. Without enough of it – we’re talking the restorative, high-quality kind – you're all but daring your brain to age rapidly.
May 5, 2025 · Healthy AgingTime for Taurine: 6 Big Health and Longevity Benefits
Chances are you’ve probably come across taurine, mostly as a key ingredient found in countless ‘energy drinks’. Assuming you’re wise enough to steer clear of those artificially sweetened, often overly caffeinated beverages (and I hope you are) well, good for you, and keep up the good work. However, you might want to take a second look at taurine on its own (minus the liquid chemical bath) because, among its many benefits, taurine is a key component in boosting heart and brain health, making it a potential major player in supporting longevity and the type of vibrant healthspans all of us want to enjoy.
Apr 28, 2025 · Healthy AgingAre You ‘Inflamm-aging’? 8 Tips for Aging Well – With Loads Less Inflammation
It’s chronic inflammation that’s implicated in just about all of our common “diseases of aging”: cardiovascular disease, type 2 diabetes, arthritis, Alzheimer’s, even some forms of cancers. But what more recent research is telling us is that chronic inflammation isn’t just driving individual diseases, it’s driving aging itself – it’s one of the key “hallmarks of aging” and it’s linked to most of the other hallmarks as well. In fact, chronic inflammation is so important, scientists often use the term “inflammaging” as a way to grapple with aging in its entirety. To live as long and well, learning how to “inflame-age” as slowly as possible is an essential first step.